Ferrostatin-1（鐵抑素-1）

Ferrostatin-1 (Fer-1) 是一種有效的、選擇性的 ferroptosis 抑制劑，抑制 Erastin 誘導的 HT-1080 細胞鐵死亡 (EC₅₀=60 nM)。Ferrostatin-1 是一種人工合成的抗氧化劑，通過還原機制來防止膜脂的損傷，從而抑制細胞死亡。具有抗真菌活性。

體外研究(In Vitro)

Ferrostatin-1 (Fer-1) prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices^[1].
Fer-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability

體內(nèi)研究(In Vivo)

Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction ^[2].
Ferrostatin-1 (0.8?mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI)^[4].
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis

分子量：262.35

Formula：C₁₅H₂₂N₂O₂

CAS 號：347174-05-4

運輸條件:Room temperature in continental US; may vary elsewhere.

儲存方式:

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)