產(chǎn)品概述

線粒體膜電位熒光探針JC-1是美國AAT Bioquest生產(chǎn)的用于線粒體膜電位檢測(cè)的試劑，JC-1廣泛用于通過流式細(xì)胞術(shù)確定線粒體膜電位。它能夠選擇性地進(jìn)入線粒體，并且隨著線粒體膜電位增加（超過約80-100mV的值）可逆地將其顏色從綠色變?yōu)槌壬＿@種性質(zhì)是由于線粒體膜極化后JC-1聚集體的可逆形式導(dǎo)致發(fā)射光從530nm（即JC-1單體形式的發(fā)射）轉(zhuǎn)變?yōu)?90nm（即J-聚集形式的發(fā)射）。當(dāng)在490nm處激發(fā)時(shí)，隨著線粒體膜變得更加極化，JC-1的顏色從綠色橙色可逆地變?yōu)榫G色橙色。

參考文獻(xiàn)

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overexpression of protocadherin 7 inhibits neuronal survival by downregulating Birc5 in vitro
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Journal: Experimental cell research (2018): 71--80